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Drug to reduce children’s peanut allergies shows early promise

Illustration for article titled Drug to reduce children’em/ems peanut allergies shows early promiseem/em
Photo: ChesiireCat (iStock)

A study released over the weekend points to a peanut allergy drug with “lifesaving” potential, according to The New York Times. On Sunday, the results of a study were announced at the American College Of Allergy, Asthma & Immunology conference in Seattle, which “may lead to approval of what could be the first oral medication that ameliorates reactions in children with severe peanut allergies.”

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In the yearlong clinical trial, 842 participants, including 750 children and adolescents, were exposed to peanut protein in gradually increasing quantities to reduce allergy sensitivity, under strict medical supervision and starting with minute quantities. The drug and the study were both designed by Aimmune Therapeutics, a clinical-stage biopharmaceutical company.

The New York Times states that after six months of treatment and six months of maintenance therapy, two-thirds of the younger participants were able to ingest the equivalent of two peanuts without adverse effects, compared to only 4 percent of the children and adolescents who received placebo treatments. Interestingly, the drug was much more effective with “children and adolescents 4 to 17 years of age. The effect in participants 18 to 55 years of age was not significant.” The Times notes the drug doesn’t “cure” peanut allergies, but could reduce the severity of children’s reactions to small amounts of peanut products.

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The resulting drug, referred to as AR101 in the study, contained defatted peanut flour designed to help users eventually reduce sensitivity to peanut exposure. It’s important to note that the treatment was not successful for all participants, and some had to drop out due to adverse effects to peanut exposure. Still, excitement for this new drug is so great that “it will receive priority review and go through an accelerated approval process, so it could be on the market by the end of 2019,” according to an Aimmune Therapeutics spokesperson.

Gwen Ihnat is the Editorial Coordinator for The A.V. Club.

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DISCUSSION

I’m very curious about the rise of peanut allergies. When I was a kid (old man take coming), I don’t really remember any kids with peanut allergies. Now, it seems like if you bring peanut butter into an elementary school, you are much more likely to have a national backlash than if you bring a gun and kill a bunch of the fuckers (we need an NPA is what I’m saying).

Seriously, though, it seems like 10% of all Braxtons, Madysyns, Jaylyns, and Xandyrs have a peanut allergy such that one dust of nut will kill them in 10 seconds.  Like that 15 year old that ate a Reese’s cookie not long ago.